Based on pharmacokinetic principles and data from intranasal GLP-1 studies, intranasal retatrutide would likely require daily or even twice-daily administration to maintain meaningful receptor activation
In the central nervous system, GLP-1 receptors are located in the hypothalamus, which is involved in regulating food intake [24, 29, 30]
What is the best way to prevent constipation while on a GLP-1
instead, we follow a careful titration schedule
Its half-life sits at approximately 168 hours, roughly seven days, which is why the standard dosing protocol calls for once-weekly injections
Some people pause or stop after sustained stability and strong lifestyle supports, while others resume therapy later if weight or glycemia drift