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Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy

Glucuronidation (50-60%) - SAFE Primary detoxification pathway in adults Makes acetaminophen water-soluble for excretion INCREASES during pregnancy but cannot compensate for other pathway changes Severely underdeveloped in fetuses/newborns 2

Losing muscle can reduce metabolic rate, making it harder to sustain weight loss and leading to a host of other health issues, such as decreased strength and mobility

Aging 13 (6), 78287845

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High doses, repeated administration, vulnerable populations (pregnant animals), and sensitive tissues (gastrointestinal tract, reproductive organs) have all been evaluated