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Those with long-term vitamin B12 deficiency need hydroxocobalamin 1000 mcg shots daily for one week, followed by weekly injections for two months
Journal of experimental pharmacology, 4, 149155
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Some community members are running this sequence deliberately: start with NAD+ precursors (NMN/NR) to raise the baseline pool, then add MOTS-C to put that pool to work, then layer in 5-Amino-1MQ to block the pathway that drains it
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