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Both semaglutide and tirzepatide carry a boxed warning for thyroid C-cell tumors based on rodent studies, and both are contraindicated in patients with a personal or family history of medullary thyroid carcinoma or MEN 2
In contrast, liraglutide still reduced food intake in mice with GLP-1R knockout limited to autonomic neurons including vagal afferent neurons (phox2b-Cre
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