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Anthracyclines induce double-strand DNA breaks at active gene promoters

Glutamine-mediated epigenetic regulation of cflip underlies resistance to trail in pancreatic cancer

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141 Common side effects include gastrointestinal reactions, such as nausea and vomiting, which are typically more common during the initial stages of treatment

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Alternative repletion strategies have focused on oral administration of GSH precursors (e.g., cysteine and glycine supplementation 9 ), and intravenous administration of GSH, 10 which although promising, is invasive and inconvenient, and therefore unlikely to be a practical solution