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In contrast with P478L, this second mutation abrogates both carnitine and organic cations transport
Furthermore, we show that targeting mitochondrial metabolism, particularly by inhibiting Complex I, sensitizes CRC cells to 5FU, resulting in delayed tumour growth and prolonged survival in preclinical models
It also aids in the hepatic biotransformation and detoxification process by functioning as a hydrophilic molecule that is added to other lipophilic wastes or toxins prior to their biliary evacuation
the PDA, by lowering prostaglandin concentrations
Off phase: 30 days pause
Nov 2022;13(11):1834-1841
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