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A five-month treatment with PEGylated exenatide (NLY01) was found to decrease the secretion of complement 1q (C1q), IL-1, and TNF- by primary mouse microglia, thereby limiting the conversion of astrocytes to a neurotoxic phenotype

This alternative is quickly metabolized by the liver, thereby reducing corticosteroid-related side effects, and appears to be as effective as prednisone, says Bedford

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For transfection with GLUD1, PRMT7, AKT1 and PI3KCA plasmid or siRNA against PRMT7, the cultured HEK 293T cells were transfected using EZ Trans Cell Transfection Reagent (Life iLab) while AGS or MFC cells were transfected using Lipofectamine TM 2000 (Invitrogen), in Opti-MEM following the manufacturers instructions

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