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doi: 10.1002/hep.20023 57

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Since this characteristic strongly correlates with tumorigenicity in animals [25], we hypothesized that interventions inhibiting TIC growth in 3D gels could also impede tumor development in vivo

These nanostructures form ternary complexes that undergo integrin-mediated endocytosis and efficient lysosomal trafficking, enabling potent degradation of pathological proteins like CD71 and PTK7, which in turn triggers cell-cycle arrest, apoptosis, and tumor suppression in vivo [74]