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The ATP7A transporter is crucial for copper transport from fibroblasts into the liver and the ATP7B is crucial for copper export from the liver
Affected dogs are usually euthanized at an early age due to poor prognosis
Clinical signs of affected puppies are deafness assessed by abnormal behaviour or by BAER (brainstem auditory evoked response) examinations
oedema and apathy
Mutation: FNIP2 gene
Dilatative Kardiomyopathie (DCM) - Welsh Springer Spaniel globo-product-options The ATP7A transporter is crucialDilated Cardiomyopathy (DCM) is a hereditary disease known in animals and humans with many similarities including familial nature, clinical signs and phenotypic features. It is characterised by cardiac enlargement (cardiomegaly) and decreased myocardial function. Due to heart arrhythmias affected individuals suffer from heart failure or collapse. The symptoms in dogs usually occur 20 months postnatal and include ventricular dilation, systolic
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