Multifokale Retinopathie 3 (CMR3) option-set-443684-checkbox-1 Lentikonus

Lentikonus

was zu einer weiß-cremefarbenen Haut mit rosa Nase

The clinical signs appear around 3–12 months of age in most dogs and progresses before the age of two years

Mutation: KCNJ10 gene

Ornithin- und Argininspiegel im Urin betroffener Hunde waren deutlich erhöht

Multifokale Retinopathie 3 (CMR3) option-set-443684-checkbox-1 LentikonusCanine multifocal retinopathies (CMR) are a group of inherited eye diseases. The diseases were reported in mastiff related breeds (CMR1), Coton de Tulear (CMR2) and in Lapponian herder (CMR3). CMR1 is found in different dog breeds, whereas CMR2 and CMR3 are so far exclusive to a single dog breed each. While exhibiting similar clinical symptoms comparable to CMR1 and CMR2, CMR3 is predicted to be based on a distinctly different molecular mechanism.